Jadwal UFC 259 Minggu 7 Maret 2021, Live Jan Blachowicz vs Israel Adesanya di ESPN Plus & Fox Sports

- Petr Yan vs. Aljamain Sterling (perebutan gelar juara kelas bantam)

- Islam Makhachev vs. Drew Dober (kelas ringan)

- Thiago Santos vs. Aleksandar Rakic (kelas berat-ringan)

Preliminary card, mulai pukul 08.00 WIB

- Dominick Cruz vs. Casey Kenny (kelas bantam)

- Song Yadong vs. Kyler Phillips (kelas bantam)

- Joseph Benavidez vs. Askar Askarov (kelas terbang)

- Rogerio Bontorin vs. Kai Kara-France (kelas terbang)

Early Preliminary, mulai pukul 06.00 WIB

- Tim Elliott vs. Jordan Espinosa (kelas terbang)

- Carlos Ulberg vs. Kennedy Nzechukwu (kelas berat ringan)

- Sean Brady vs. Jake Matthews (kelas welter)

- Amanda Lemos vs. Livia Renata Souza (kelas jerami wanita)

- Uros Medic vs. Aalon Cruz (kelas ringan)

- Mario Bautista vs Trevin Jones (kelas bantam)